Award

2021 

Randy YC Poon has been awarded the Croucher Senior Research Fellowships 2021. This is the second time that Prof. Poon has been awarded the Senior Research Fellowship Award after receiving it in 2002.

 

www.hku.hk/www/edm/readmail.php?id=5134

Research Projects

2021 

Randy YC Poon and Fangwei Wang (Zhejiang University) have been awarded a grant from the NSFC–RGC Joint Research Scheme to conduct collaborative studies on Aurora A kinase and Bora.

Research Projects

2021 

Randy YC Poon has been awarded a grant from the RGC GRF to study cyclin-dependent kinases.

Keeping it in the family – the implication of multiple cyclin-dependent kinases in human cells

  

 

Paper

2020: Lok and co. discovered that weakening of the spindle-assembly checkpoint is a mechanism underlying mitotic slippage. As mitotic slippage is critical for both cancer development and effectiveness of a major class of cancer therapies, these new findings extend our fundamental understanding of how cancer cells develop in the first place and subsequently respond to therapies.  

 

Lok TS, Wang Y, Xu WK, Xie S, Ma HT, and Poon RYC (2020) Mitotic slippage is determined by p31comet and the weakening of the spindle-assembly checkpoint.  Oncogene 39: 2819-34.

Paper

2020: Joyce Mak demonstrated that inactivation of ATM acts synergistically with PARP1 inhibitors in promoting cell death in cancer cells. This study implies that ATM is an important anti-cancer target for therapies using PARP inhibitors.  

 

Mak JPY, Ma HT, and Poon RYC (2020)  Synergism between ATM and PARP1 inhibition involves DNA damage and abrogating the G2 DNA damage checkpoint.  Molecular Cancer Therapeutics 19: 123-134.

Research Projects

2020:  Research grants recently awarded to the group:

• RGC GRF (Randy YC Poon)

     The origins and aftermaths of mitotic slippage

• RGC GRF (Ken Ma)

     Investigating the novel roles of TRIP13 in MDM2/MDM4-p53 regulation

• Health and Medical Research Fund (Ken Ma)

     Role of TRIP13 gene in hepatocelluar carcinoma development & disease progression 

Meeting

30 May 2019 

2nd Workshop on Mitotic Fidelity, HKUST.

Organizer: R.Y.C. Poon

 

Speakers:  Franco Au (HKUST), Gary Chan (HKU), William Chao (U Macau), Yick Hin Ling (HKU), Ken Ma (HKUST)

Resources

2019: a superior conditional KO system generated using CRISPR-Cas9 and rescue constructs under the control of Tet promoter and AID degron. Great for studying essential genes.

Vectors described in the paper can be obtained from Addgene.

Ng LY, Ma HT, Liu JCY, Huang X, Lee N, and Poon RYC (2019) Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation. Cell Cycle 18: 238-48.

Paper

2019: Zeng and co. addressed an important issue in anti-cancer drug responses. They found that mitotic slippage prevents mitotic cell death caused by spindle poisons but reduces subsequent long term survival. The specific temporal patterns of cell death may reconcile the contradictory results from many previous studies.  

 

Zeng X, Xu WK, Lok TM, Ma HT, and Poon RYC (2019) Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics. Cell Death and Disease 10: 314.

Research Project

2018

An industrial collaborative project with the CK Life Sciences International Inc on the development of cancer vaccines and immune checkpoint inhibitors is funded by the Innovation & Technology Council.

  

Paper

2018: Ken Ma published a complementary paper to our 2016 study on TRIP13. This new study finally explains the paradox of why TRIP13 is required for the activation of the spindle-assembly checkpoint (in addition to its role in inactivating the checkpoint). 

Ma HT and Poon RYC (2018) TRIP13 functions in the establishment of the spindle-assembly checkpoint by replenishing O-MAD2. Cell Reports 22: 1439-50.

Ma HT and Poon RYC (2016) TRIP13 regulates both the activation and inactivation of the spindle-assembly checkpoint. Cell Reports 14: 1086-99.

Research Projects

2018:  Research grants recently awarded to the group:

 

• RGC GRF (Randy YC Poon) 

Cyclin A: reassessing its mitotic functions with new arsenal

• RGC GRF (Ken Ma) 

Understanding the role of TRIP13 and MAD2 conformation equilibrium in spindle assembly checkpoint

• RGC CRF (Randy YC Poon co-PI) 

High-resolution live-cell imaging system for quantifying long-term 3D dynamics of large tissue models and organisms

© 2021 by Randy Y.C. Poon