And everybody knows that its now or never.
Everybody knows that its me or you.
And everybody knows that you live forever when you’ve done a line or two.
Everybody knows the deal is rotten: Old Black Joe’s still pickin’ cotton for your ribbons and bows.
And everybody knows.
Leonard Cohen: “Everybody Knows” from“I’m Your Man” (1988)
Mak JPY, Ma HT and Poon RYC (2019)
Synergism between ATM and PARP1 inhibition involves DNA damage and abrogating the G2 DNA damage checkpoint.
Molecular Cancer Therapeutics in press.
Ng LY, Ma HT, Liu JCY, Huang X, Lee N, and Poon RYC (2019)
Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation.
Cell Cycle 18: 238-48.
Zeng X, Xu WK, Lok TM, Ma HT, and Poon RYC (2019)
Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics.
Cell Death and Disease 10: 314.
Ma HT and Poon RYC (2018)
TRIP13 functions in the establishment of the spindle-assembly checkpoint by replenishing O-MAD2.
Cell Reports 22: 1439-50.
Poon RYC (2018)
Cyclin A.
In Encyclopedia of Signalling Molecules. Second Edition. Ed. Sangdun Choi. Springer, New York. p. 1254-9.
Ma HT and Poon RYC (2017)
Synchronization of HeLa cells.
Methods Mol. Biol. 1524: 189-201.
Wang XQ, Lo CM, Chen L, Ngan ES, Xu A, and Poon RYC (2017)
CDK1-PDK1-PI3K/Akt-signaling pathway regulates embryonic and induced pluripotency.
Cell Death & Differentiation 24: 38-48.
Xia W, Lo CM, Poon RYC, Cheung TT, Chan ACY, Chen L, Yang S, Tsao GSW, and Wang XQ (2017)
Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells.
Oncotarget 8: 38811-24.
Ye F, Kang E, Yu C, Qian X, Jacab F, Yu C, Mao M, Poon RYC, Kim J, Song H, Ming G, Zhang M (2017)
DISC1 regulates neurogenesis via modulating kinetochore attachment of Ndel1/Nde1 during mitosis.
Neuron 96: 1041-54.
Huang S, Tang R, and Poon RYC (2016)
BCL-W is a regulator of microtubule inhibitor-induced mitotic cell death.
Oncotarget 7: 38718-30.
Ma HT and Poon RYC (2016)
TRIP13 regulates both the activation and inactivation of the spindle-assembly checkpoint.
Cell Reports 14: 1086-99.
Poon RYC (2016)
Cell cycle control: a system of interlinking oscillators.
Methods Mol. Biol. 1342: 3-19.
Wong PY, Ma HT, Lee H, and Poon RYC (2016)
MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation.
Scientific Reports 6: 22230.
Li J, Hong MJ, Chow JPH, Man WY, Mak JPY, Ma HT, and Poon RYC (2015)
Co-inhibition of Polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe.
Oncotarget 6: 9327-40.
Mak JPY, Man WY, Chow JPH, Ma HT, and Poon RYC (2015)
Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells.
Oncotarget 6: 21074-84.
Poon RYC (2015)
Cell cycle control.
Reference Module in Biomedical Sciences. Elsevier. 08-Aug-2015 doi: 10.1016/B978-0-12-801238-3.98748-8.
Poon RYC (2015)
Mitotic catastrophe.
In Encyclopedia of Cell Biology, 1st Edition. Ed Bradshaw & Stahl. Academic Press, San Diego, p 399-403.
Wong WK, Kelly T, Li J, Ma HT, and Poon RYC (2015)
SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A–B56.
Cell Cycle 14: 3965-77.
Xie S, Mortusewicz O, Ma HT, Herr P, Poon RYC, Helleday T, and Qian C (2015)
Timeless interacts with PARP-1 to promote homologous recombination repair.
Molecular Cell 60: 163-76.
Chen H, Huang S, Han X, Zhang J, Shan C, Tsang YH, Ma HT, and Poon RYC (2014)
Salt-Inducible Kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutics-mediated cell death.
Cell Death & Disease 5: e1177.
Ma HT, Erdal S, Huang S, and Poon RYC (2014)
Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance.
Molecular Oncology 8: 1408-18.
Mak JPY, Man WY, Ma HT, and Poon RYC (2014)
Pharmacological targeting the ATR–CHK1–WEE1 axis involves balancing cell growth stimulation and apoptosis.
Oncotarget 5:10546-57.
Man WY, Mak JPY, and Poon RYC (2014)
Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint.
J. Cell. Mol. Med.18: 143-55.
Marxer M, Ma HT, Man WY, and Poon RYC (2014)
p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases.
Oncogene 33: 3550-60.
Poon RYC (2014)
DNA damage checkpoints in nasopharyngeal carcinoma.
Oral Oncology 50: 339-44.
Wang XQ, Chan KK, Ming X, Lui VCH, Poon RYC, Lo CM, Norbury C, and Poon RTP (2014)
G1 checkpoint establishment in vivo during embryonic liver development.
BMC Devel. Biol. 14: 23.
Xing X, Poon RYC, Wong CSC, and Yobas L (2014)
Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes.
Biosensors and Bioelectronics 61: 434-42.
Chow JPH, Man WY, Mao M, Chen H, Cheung F, Nicholls J, Tsao GSW, Lung ML, and Poon RYC (2013)
Poly(ADP-ribose) polymerase 1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy.
Mol. Cancer Therap. 12: 2517-28.
Chow JPH and Poon RYC (2013)
The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery.
Oncogene 32: 4778-88.
Han X and Poon RYC (2013)
Critical differences between isoforms of Securin reveal mechanisms of Separase regulation.
Mol. Cell. Biol. 33: 3400-15 (Spotlight article).
Poon RYC (2013)
News and Views. Aurora B: hooking up with cyclin-dependent kinases.
Cell Cycle 12: 1019-20.
Chen Y, Chow JPH, and Poon RYC (2012)
Inhibition of Eg5 acts synergistically with checkpoint abrogation in promoting mitotic catastrophe.
Mol. Cancer Res. 10: 626-35.
Ma HT, Chan YY, Chen X, On KF, and Poon RYC (2012)
Depletion of p31comet promotes sensitivity to antimitotic drugs.
J. Biol. Chem. 287: 21561-9.
Marxer M, Foucar CE, Man WY, Chen Y, Ma HT, and Poon RYC (2012)
Tetraploidization increases sensitivity to Aurora B kinase inhibition.
Cell Cycle 11: 2567-77.
Poon RYC (2012)
Cyclin A.
In Encyclopedia of Signalling Molecules. Ed. Sangdun Choi. Springer, New York. p. 491-6.
Tsang YH, Han X, Man WY, Lee N, and Poon RYC (2012)
Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints.
PLos ONE 7: e49943.
Chow JPH, Poon RYC, and Ma HT (2011)
Inhibitory phosphorylation of CDK1 as a compensatory mechanism for mitotic exit.
Mol. Cell. Biol. 31: 1478-91.
Ma HT and Poon RYC (2011)
Orderly inactivation of the key checkpoint protein Mitotic Arrest Deficient 2 (MAD2) during mitotic progression.
J. Biol. Chem. 286: 13052-9.
Ma HT and Poon RYC (2011)
How protein kinases coordinate mitosis in animal cells.
Biochem. J. 435: 17-31.
Ma HT and Poon RYC (2011)
Synchronization of HeLa cells.
Methods Mol. Biol. 761: 151-61.
On KF, Chen Y, Ma HT, Chow JPH, and Poon RYC (2011)
Determinants of mitotic catastrophes upon abrogation of the G2 DNA damage checkpoint by UCN-01.
Mol. Cancer Therap. 10: 784-94.
Poon RYC (2011)
Biomedical research in Hong Kong.
The Biochemist 33: 24-25.
Uchida S, Watanabe N, Kudo Y, Yoshioka K, Matsunaga T, Ishizaka Y, Nakagama H, Poon RYC, Yamashita K (2011)
SCFbeta-TrCP mediates stress-activated MAP kinase-induced Cdc25B degradation.
J. Cell Science 124: 2816-25.
Chow JPH and Poon RYC (2010)
DNA damage and polyploidization.
In Polyploidization and Cancer. Ed. Randy YC Poon Springer, New York. p. 55-69.
Chow JPH and Poon RYC (2010)
Mitotic catastrophe.
In Cell Cycle Deregulation in Cancer 79-96. Ed. Greg Enders. Springer, New York.
Ho CC, Hau PM, Marxer M, and Poon RYC (2010)
The requirement of p53 for maintaining chromosomal stability during tetraploidization.
Oncotarget 1: 583-95 (cover story).
Ma HT and Poon RYC (2010)
Genome reduplication: redeployment of cyclin-CDK complexes and spontaneous oscillation of APC/C.
Cell Cycle 9: 431-2.
Ma HT and Poon RYC (2010)
Gene downregulation with short hairpin RNAs and validation of specificity by inducible rescue in mammalian cells.
Current Protocols in Cell Biology Chapter 27:Unit27.2.
Poon RYC (book editor) (2010)
Polyploidization and Cancer.
Springer, New York.
Chan YW, Chen Y, and Poon RYC (2009)
Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe.
Oncogene 28: 170-83.
Ma HT, Tsang YH, Marxer M, and Poon RYC (2009)
Cyclin A2-CDK2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-APC/C axis to promote genome reduplication in the absence of mitosis.
Mol. Cell. Biol. 29: 6500-14.
Uchida S, Yoshioka K, Kizu R, Nakagama H, Matsunaga T, Ishizaka Y, Poon RYC, and Yamashita K (2009)
Stress-activated MAP kinases JNK and p38 target Cdc25B for degradation.
Cancer Res. 69: 6438-44.
Wang XQ, Liu VCH, Poon RTP, Lu P, and Poon RYC (2009)
DNA damage-mediated S and G2 checkpoints in human embryonal carcinoma cells.
Stem Cells 27: 568-76.
Chan YW, Ma HT, Wong W, Ho CC, On KF, and Poon RYC (2008)
CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis.
Cell Cycle 7: 1149-61.
Chan YW, On KF, Chan WM, Wong W, Siu HO, Hau PM, and Poon RYC (2008)
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint.
J. Biol. Chem. 283: 15716-23.
Chen Y and Poon RYC (2008)
The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability.
Frontiers Biosciences 13: 5016-29.
Chan WM and Poon RYC (2007)
The p53 isoform ∆p53 lacks intrinsic transcriptional activity and reveals the critical role of nuclear import in dominant-negative activity.
Cancer Res. 67: 1959-69.
Fung TK, Ma HT, and Poon RYC (2007)
Specialized roles of the two mitotic cyclins in somatic cells: Cyclin A as an activator of M phase-promoting factor.
Mol. Biol. Cell 18: 1861-73.
Poon RYC (2007)
Mitotic phosphorylation: breaking the balance of power by a tactical retreat.
Biochem. J. 403: e5-7.
Poon RYC and Fung TK (2007)
Cyclin A2.
AfCS-Nature Molecule Pages (doi:10.1038/mp.a000717.01).
Ma HT, On KF, Tsang YH, and Poon RYC (2007)
An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells.
Nucleic Acids Res. 35: e22 (doi: 10.1093/nar/gkl1109).
Zhang W, Chan HM, Poon RYC, and Wu Z (2007)
BS69 is involved in cellular senescence through the p53-p21cip1 pathway.
EMBO Reports 8: 952-8.
Fung TK and Poon RYC (2006)
Cyclin A1.
AfCS-Nature Molecule Pages (doi:10.1038 /mp.a000716.01).
Chan WM, Mak MC, Fung TK, Lau A, Siu WY, and Poon RYC (2006)
Ubiquitination of p53 at multiple sites in the DNA binding domain.
Mol. Cancer Res. 4: 15-25.
Hau PM, Siu WY, Wong N, Lai PBS, and Poon RYC (2006)
Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells.
FEBS Letters 580: 4727-36.
Ho CC, Siu WY, Lau A, Chan WM, Arooz T, and Poon RYC (2006)
Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways.
Cancer Res. 66: 2233-41.
Kim S, Lau TTY, Liao MK, Ma HT, and Poon RYC (2024)
Co-regulation of NDC80 complex subunits determines the fidelity of the spindle-assembly checkpoint and mitosis.
Molecular Cancer Research in press.
Yu CY, Yeung TK, Fu WK, and Poon RYC (2024)
BCL-XL regulates the timing of apoptosis independently of BCL2 and MCL1 compensation.
Cell Death & Disease 15: 2.
Lau TY and Poon RYC (2023)
Whole-genome duplication and genome instability in cancer cells: double the trouble.
International Journal of Molecular Sciences 24: 3733.
Ng LY, Ma HT, and Poon RYC (2023)
Cyclin A–CDK1 suppresses the expression of the CDK1 activator CDC25A to safeguard timely mitotic entry.
Journal of Biological Chemistry 299: 102957.
Yeung TK, Kim S, Ma HT, and Poon RYC (2023)
A robust dual gene ON-OFF toggle directed by two independent promoter-degron pairs.
Journal of Cell Science 136: jsc260754.
Poon RYC (2022)
Mitotic catastrophe.
Encyclopedia of Cell Biology, Second Edition 5: 201-6. In: Bradshaw RA, Hart GW, Stahl PD (eds.) Oxford: Elsevier.
Wang Y and Poon RYC (2022)
MARCH5 regulates mitotic apoptosis through MCL1-dependent and -independent mechanisms.
Cell Death & Differentiation 30: 753-65.
Lau HW, Ma HT, Yeung TK, Tam MY, Zheng D, Chu SK, and Poon RYC (2021)
Quantitative differences between cyclin-dependent kinases underlie the unique functions of CDK1 in human cells.
Cell Reports 37: 109808.
Poon RYC (2021)
Cell cycle control: a system of interlinking oscillators.
Methods in Molecular Biology 2329: 1-18.
Yeung TK, Lau HW, Ma HT, and Poon RYC (2021)
One-step multiplex toolkit for efficient generation of conditional gene silencing human cell lines.
Molecular Biology of the Cell 32: 1320-30.
Lok TS, Wang Y, Xu WK, Xie S, Ma HT, and Poon RYC (2020)
Mitotic slippage is determined by p31comet and the weakening of the spindle-assembly checkpoint.
Oncogene 39: 2819-34.
Ma HT and Poon RYC (2020)
Aurora kinases and DNA damage response.
Mutation Research 821: 111716.
Mak JPY, Ma HT, and Poon RYC (2020)
Synergism between ATM and PARP1 inhibition involves DNA damage and abrogating the G2 DNA damage checkpoint.
Molecular Cancer Therapeutics 19: 123-134.
Ng LY, Ma HT, Liu JCY, Huang X, Lee N, and Poon RYC (2019)
Conditional gene inactivation by combining tetracycline-mediated transcriptional repression and auxin-inducible degron-mediated degradation.
Cell Cycle 18: 238-48.
Zeng X, Xu WK, Lok TM, Ma HT, and Poon RYC (2019)
Imbalance of the spindle-assembly checkpoint promotes spindle poison-mediated cytotoxicity with distinct kinetics.
Cell Death & Disease 10: 314.
Ma HT and Poon RYC (2018)
TRIP13 functions in the establishment of the spindle-assembly checkpoint by replenishing O-MAD2.
Cell Reports 22: 1439-50.
Poon RYC (2018)
Cyclin A.
In Encyclopedia of Signalling Molecules. Second Edition. Ed. Sangdun Choi. Springer, New York. p. 1254-9.
Ma HT and Poon RYC (2017)
Synchronization of HeLa cells.
Methods in Molecular Biology 1524: 189-201.
Wang XQ, Lo CM, Chen L, Ngan ES, Xu A, and Poon RYC (2017)
CDK1-PDK1-PI3K/Akt-signaling pathway regulates embryonic and induced pluripotency.
Cell Death & Differentiation 24: 38-48.
Xia W, Lo CM, Poon RYC, Cheung TT, Chan ACY, Chen L, Yang S, Tsao GSW, and Wang XQ (2017)
Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells.
Oncotarget 8: 38811-24.
Ye F, Kang E, Yu C, Qian X, Jacab F, Yu C, Mao M, Poon RYC, Kim J, Song H, Ming G, Zhang M (2017)
DISC1 regulates neurogenesis via modulating kinetochore attachment of Ndel1/Nde1 during mitosis.
Neuron 96: 1041-54.
Huang S, Tang R, and Poon RYC (2016)
BCL-W is a regulator of microtubule inhibitor-induced mitotic cell death.
Oncotarget 7: 38718-30.
Ma HT and Poon RYC (2016)
TRIP13 regulates both the activation and inactivation of the spindle-assembly checkpoint.
Cell Reports 14: 1086-99.
Poon RYC (2016)
Cell cycle control: a system of interlinking oscillators.
Methods in Molecular Biology 1342: 3-19.
Poon RYC (2015)
Mitotic catastrophe.
In Encyclopedia of Cell Biology, 1st Edition. Ed Bradshaw & Stahl. Academic Press, San Diego, p 399-403.
Wong PY, Ma HT, Lee H, and Poon RYC (2016)
MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation.
Scientific Reports 6: 22230.
Li J, Hong MJ, Chow JPH, Man WY, Mak JPY, Ma HT, and Poon RYC (2015)
Co-inhibition of Polo-like kinase 1 and Aurora kinases promotes mitotic catastrophe.
Oncotarget 6: 9327-40.
Mak JPY, Man WY, Chow JPH, Ma HT, and Poon RYC (2015)
Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells.
Oncotarget 6: 21074-84.
Poon RYC (2015)
Cell cycle control.
Reference Module in Biomedical Sciences. Elsevier. 08-Aug-2015 doi: 10.1016/B978-0-12-801238-3.98748-8.
Wong WK, Kelly T, Li J, Ma HT, and Poon RYC (2015)
SGO1C is a non-functional isoform of Shugoshin and can disrupt sister chromatid cohesion by interacting with PP2A–B56.
Cell Cycle 14: 3965-77.
Xie S, Mortusewicz O, Ma HT, Herr P, Poon RYC, Helleday T, and Qian C (2015)
Timeless interacts with PARP-1 to promote homologous recombination repair.
Molecular Cell 60: 163-76.
Chen H, Huang S, Han X, Zhang J, Shan C, Tsang YH, Ma HT, and Poon RYC (2014)
Salt-Inducible Kinase 3 is a novel mitotic regulator and a target for enhancing antimitotic therapeutics-mediated cell death.
Cell Death & Disease 5: e1177.
Ma HT, Erdal S, Huang S, and Poon RYC (2014)
Synergism between inhibitors of Aurora A and KIF11 overcomes KIF15-dependent drug resistance.
Molecular Oncology 8: 1408-18.
Mak JPY, Man WY, Ma HT, and Poon RYC (2014)
Pharmacological targeting the ATR–CHK1–WEE1 axis involves balancing cell growth stimulation and apoptosis.
Oncotarget 5:10546-57.
Man WY, Mak JPY, and Poon RYC (2014)
Dovitinib induces mitotic defects and activates the G2 DNA damage checkpoint.
Journal of Cellular and Molecular Medicine 18: 143-55.
Marxer M, Ma HT, Man WY, and Poon RYC (2014)
p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases.
Oncogene 33: 3550-60.
Poon RYC (2014)
DNA damage checkpoints in nasopharyngeal carcinoma.
Oral Oncology 50: 339-44.
Wang XQ, Chan KK, Ming X, Lui VCH, Poon RYC, Lo CM, Norbury C, and Poon RTP (2014)
G1 checkpoint establishment in vivo during embryonic liver development.
BMC Developmental Biology 14: 23.
Xing X, Poon RYC, Wong CSC, and Yobas L (2014)
Label-free enumeration of colorectal cancer cells from lymphocytes performed at a high cell-loading density by using interdigitated ring-array microelectrodes.
Biosensors and Bioelectronics 61: 434-42.
Chow JPH, Man WY, Mao M, Chen H, Cheung F, Nicholls J, Tsao GSW, Lung ML, and Poon RYC (2013)
Poly(ADP-ribose) polymerase 1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy.
Molecular Cancer Therapeutics 12: 2517-28.
Chow JPH and Poon RYC (2013)
The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery.
Oncogene 32: 4778-88.
Han X and Poon RYC (2013)
Critical differences between isoforms of Securin reveal mechanisms of Separase regulation.
Molecular and Cellular Biology 33: 3400-15 (Spotlight article).
Poon RYC (2013)
News and Views. Aurora B: hooking up with cyclin-dependent kinases.
Cell Cycle 12: 1019-20.
Chen Y, Chow JPH, and Poon RYC (2012)
Inhibition of Eg5 acts synergistically with checkpoint abrogation in promoting mitotic catastrophe.
Molecular Cancer Research 10: 626-35.
Ma HT, Chan YY, Chen X, On KF, and Poon RYC (2012)
Depletion of p31comet promotes sensitivity to antimitotic drugs.
Journal of Biological Chemistry 287: 21561-9.
Marxer M, Foucar CE, Man WY, Chen Y, Ma HT, and Poon RYC (2012)
Tetraploidization increases sensitivity to Aurora B kinase inhibition.
Cell Cycle 11: 2567-77.
Poon RYC (2012)
Cyclin A.
In Encyclopedia of Signalling Molecules. Ed. Sangdun Choi. Springer, New York. p. 491-6.
Tsang YH, Han X, Man WY, Lee N, and Poon RYC (2012)
Novel functions of the phosphatase SHP2 in the DNA replication and damage checkpoints.
PLos ONE 7: e49943.
Chow JPH, Poon RYC, and Ma HT (2011)
Inhibitory phosphorylation of CDK1 as a compensatory mechanism for mitotic exit.
Molecular and Cellular Biology 31: 1478-91.
Ma HT and Poon RYC (2011)
Orderly inactivation of the key checkpoint protein Mitotic Arrest Deficient 2 (MAD2) during mitotic progression.
Journal of Biological Chemistry 286: 13052-9.
Ma HT and Poon RYC (2011)
How protein kinases coordinate mitosis in animal cells.
Biochemical Journal 435: 17-31.
Ma HT and Poon RYC (2011)
Synchronization of HeLa cells.
Methods in Molecular Biology 761: 151-61.
On KF, Chen Y, Ma HT, Chow JPH, and Poon RYC (2011)
Determinants of mitotic catastrophes upon abrogation of the G2 DNA damage checkpoint by UCN-01.
Molecular Cancer Therapeutics 10: 784-94.
Poon RYC (2011)
Biomedical research in Hong Kong.
The Biochemist 33: 24-25.
Uchida S, Watanabe N, Kudo Y, Yoshioka K, Matsunaga T, Ishizaka Y, Nakagama H, Poon RYC, Yamashita K (2011)
SCFbeta-TrCP mediates stress-activated MAP kinase-induced Cdc25B degradation.
Journal of Cell Science 124: 2816-25.
Chow JPH and Poon RYC (2010)
DNA damage and polyploidization.
In Polyploidization and Cancer. Ed. Randy YC Poon Springer, New York. p. 55-69.
Chow JPH and Poon RYC (2010)
Mitotic catastrophe.
In Cell Cycle Deregulation in Cancer 79-96. Ed. Greg Enders. Springer, New York.
Ho CC, Hau PM, Marxer M, and Poon RYC (2010)
The requirement of p53 for maintaining chromosomal stability during tetraploidization.
Oncotarget 1: 583-95 (cover story).
Ma HT and Poon RYC (2010)
Genome reduplication: redeployment of cyclin-CDK complexes and spontaneous oscillation of APC/C.
Cell Cycle 9: 431-2.
Ma HT and Poon RYC (2010)
Gene downregulation with short hairpin RNAs and validation of specificity by inducible rescue in mammalian cells.
Current Protocols in Cell Biology Chapter 27:Unit27.2.
Poon RYC (book editor) (2010)
Polyploidization and Cancer.
Springer, New York.
Chan YW, Chen Y, and Poon RYC (2009)
Generation of an indestructible cyclin B1 by caspase-6-dependent cleavage during mitotic catastrophe.
Oncogene 28: 170-83.
Ma HT, Tsang YH, Marxer M, and Poon RYC (2009)
Cyclin A2-CDK2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-APC/C axis to promote genome reduplication in the absence of mitosis.
Molecular and Cellular Biology 29: 6500-14.
Uchida S, Yoshioka K, Kizu R, Nakagama H, Matsunaga T, Ishizaka Y, Poon RYC, and Yamashita K (2009)
Stress-activated MAP kinases JNK and p38 target Cdc25B for degradation.
Cancer Research 69: 6438-44.
Wang XQ, Liu VCH, Poon RTP, Lu P, and Poon RYC (2009)
DNA damage-mediated S and G2 checkpoints in human embryonal carcinoma cells.
Stem Cells 27: 568-76.
Chan YW, Ma HT, Wong W, Ho CC, On KF, and Poon RYC (2008)
CDK1 inhibitors antagonize the immediate apoptosis triggered by spindle disruption but promote apoptosis following the subsequent rereplication and abnormal mitosis.
Cell Cycle 7: 1149-61.
Chan YW, On KF, Chan WM, Wong W, Siu HO, Hau PM, and Poon RYC (2008)
The kinetics of p53 activation versus cyclin E accumulation underlies the relationship between the spindle-assembly checkpoint and the postmitotic checkpoint.
Journal of Biological Chemistry 283: 15716-23.
Chen Y and Poon RYC (2008)
The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability.
Frontiers Biosciences 13: 5016-29.
Chan WM and Poon RYC (2007)
The p53 isoform ∆p53 lacks intrinsic transcriptional activity and reveals the critical role of nuclear import in dominant-negative activity.
Cancer Research 67: 1959-69.
Fung TK, Ma HT, and Poon RYC (2007)
Specialized roles of the two mitotic cyclins in somatic cells: Cyclin A as an activator of M phase-promoting factor.
Molecular Biology of the Cell 18: 1861-73.
Poon RYC (2007)
Mitotic phosphorylation: breaking the balance of power by a tactical retreat.
Biochemical Journal 403: e5-7.
Poon RYC and Fung TK (2007)
Cyclin A2.
AfCS-Nature Molecule Pages (doi:10.1038/mp.a000717.01).
Ma HT, On KF, Tsang YH, and Poon RYC (2007)
An inducible system for expression and validation of the specificity of short hairpin RNA in mammalian cells.
Nucleic Acids Research 35: e22 (doi: 10.1093/nar/gkl1109).
Zhang W, Chan HM, Poon RYC, and Wu Z (2007)
BS69 is involved in cellular senescence through the p53-p21cip1 pathway.
EMBO Reports 8: 952-8.
Chan WM, Mak MC, Fung TK, Lau A, Siu WY, and Poon RYC (2006)
Ubiquitination of p53 at multiple sites in the DNA binding domain.
Molecular Cancer Research 4: 15-25.
Fung TK and Poon RYC (2006)
Cyclin A1.
AfCS-Nature Molecule Pages (doi:10.1038 /mp.a000716.01).
Hau PM, Siu WY, Wong N, Lai PBS, and Poon RYC (2006)
Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells.
FEBS Letters 580: 4727-36.
Ho CC, Siu WY, Lau A, Chan WM, Arooz T, and Poon RYC (2006)
Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways.
Cancer Research 66: 2233-41.
Fung TK and Poon RYC (2005)
A roller coaster ride with the mitotic cyclins.
Seminars in Cell and Developmental Biology 16: 335-42.
Fung TK, Yam CH, and Poon RYC (2005)
The N-terminal regulatory domain of cyclin A contains redundant ubiquitination targeting sequences and acceptor sites.
Cell Cycle 4: 1411-20.
Ho CC, Siu WY, Chow JPH, Lau A, Arooz T, Tong HY, Ng IOL, and Poon RYC (2005)
The relative contribution of CHK1 and CHK2 to Adriamycin-induced checkpoint.
Experimental Cell Research 304: 1-15.
Poon RYC (2005)
Editorial.
Seminars in Cell and Developmental Biology 16: 309.
Chan WM, Siu WY, Lau A, and Poon RYC (2004)
How many mutant p53 molecules are needed to inactivate a tetramer?
Molecular and Cellular Biology 24: 3536-51.
Cheung N, So CW, Yam JW, So CK, Poon RYC, Jin DY, Chan LC (2004)
Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukemia.
Biochem. J. 383: 27-35.
Ng CP, Lee HC, Ho CW, Arooz T, Siu WY, Lau A, and Poon RYC (2004)
Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains.
Journal of Biological Chemistry 279: 8808-19.
Siu WY, Lau A, Arooz T, Chow JPH, Ho HTB, and Poon RYC (2004)
Topoisomerase poisons differentially activate DNA damage checkpoints through ataxia-telangiectasia mutated-dependent and -independent mechanisms.
Molecular Cancer Therapeutics. 3: 621-32.
Woo RA and Poon RYC (2004)
Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation.
Genes and Development 18: 1317-30.
Woo RA and Poon RYC (2004)
Gene mutations and aneuploidy: the instability that causes cancer.
Cell Cycle 3: 1101-3.
Chow JPH, Siu WY, Fung TK, Chan WM, Lau A, Arooz T, Ng CP, Yamashita K, and Poon RYC (2003)
DNA damage during the spindle-assembly checkpoint degrades CDC25A, inhibits cyclin-CDC2 complexes, and reverses cells to interphase.
Molecular Biology of the Cell 14: 3189-4002.
Chow JPH, Siu WY, Ho HTB, Ma KHT, Ho CC, and Poon RYC (2003)
Differential contribution of inhibitory phosphorylation of CDC2 and CDK2 for unperturbed cell cycle control and DNA integrity checkpoints.
Journal of Biological Chemistry 278: 40815-28.
Tsang FC, Po LS, Leung KM, Lau A, Siu WY, and Poon RYC (2003)
ING1b decreases cell proliferation through p53-dependent and independent mechanisms.
FEBS Letters 553: 277-85.
Woo RA and Poon RYC (2003)
Cyclin-dependent kinases and S phase control in mammalian cells.
Cell Cycle 2: 316-24.
Fung TK, Siu WY, Yam CH, Lau A, and Poon RYC (2002)
Cyclin F is degraded during G2-M by mechanisms fundamentally different to other cyclins.
Journal of Biological Chemistry 277: 35140-9.
Graeser R, Gannon J, Poon RYC, Dubois T, Aitken A, and Hunt T (2002)
Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth of neuro2A cells.
Journal of Cell Science 115: 3479-90.
Leung KM, Po LS, Tsang FC, Siu WY, Lau A, Ho HTB, and Poon RYC (2002)
The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.
Cancer Research 62: 4890-3.
Li KKW, Ng IOL, Fan ST, Albrecht JH, Yamashita K, and Poon RYC (2002)
Activation of cyclin-dependent kinases CDC2 and CDK2 in hepatocellular carcinoma.
Liver 22(3): 259-68.
Poon RYC (2002)
CAK from Marine Invertebrates to Human.
In CDK-Activating Kinase (CAK). Ed. Kaldis P. Landes Bioscience Press, Georgetown, TX. and Kluwer Academic/Plenum Publishers (ISBN 0-306-47438-7) 1-12.
Poon RYC (2002)
Cell cycle control.
In Encyclopedia of Cancer 2nd Edition. Ed. Bertino JR. Academic Press, San Diego; 393-403.
Yam CH, Fung TK, and Poon RYC (2002)
Cyclin A in cell cycle control and cancer.
Cellular and Molecular Life Sciences 59: 1317-26.
Arooz T, Chan HY, Lau WSA, Leung KM, Po LS, Siu WY, Tsang FC, and Poon RYC (2001)
Regulation of G2/M cell cycle DNA damage checkpoints.
In Molecular Genetic Basis of Cancer. Ed. Lung ML and Hsiao WLW. 230-43.
Wang XQ, Arooz T, Siu WY, Chiu CHS, Lau A, Yamashita K, and Poon RYC (2001)
MDM2 and MDMX can interact differently with ARF and members of the p53 family.
FEBS Letters 490: 202-8.
Wang XQ, Ongkeko WM, Lau AWS, Leung KA, and Poon RYC (2001)
A possible role of p73 on the modulation of p53 level through MDM2.
Cancer Research 61: 1598-603.
Yam CH, Siu WY, Kaganovich D, Ruderman JV, and Poon RYC (2001)
Cleavage of cyclin A at R70/R71 by the bacterial protease OmpT.
Proceedings of the National Academy of Sciences, USA 98: 497-501.
Arooz T, Yam CH, Siu WY, Lau A, Li KKW, and Poon RYC (2000)
On the concentrations of cyclins and cyclin-dependent kinases in extracts of cultured human cells.
Biochemistry USA 39: 9494-501.
Mal A, Chattopadhyay D, Ghosh MK, Poon RYC, Hunter T, and Harter ML (2000)
p21 and Rb control the absence of DNA replication in terminally differentiated muscle cells.
Journal of Cell Biology 149: 281-92.
Yam CH, Siu WY, Lau A, and Poon RYC (2000)
Degradation of cyclin A does not require its phosphorylation by CDC2 and cyclin-dependent kinase 2.
Journal of Biological Chemistry 275: 3158-67.
Yeung PKK, New DC, Leveson A, Yam CH, Poon RYC, and Wong JTY (2000)
The spindle checkpoint in the Dinoflagellate Crypthecodinium cohnii.
Experimental Cell Research 254:120-9.
Ongkeko WM, Wang XQ, Siu WY, Lau A, Yamashita K, Harris AL, Cox LS, and Poon RYC (1999)
MDM2 and MDMX bind and stabilize the p53-related protein p73.
Current Biol. 9: 829-32.
Siu WY, Yam CH, and Poon RYC (1999)
G1 versus G2 cell cycle arrest after adriamycin-induced damage in mouse Swiss3T3 cells.
FEBS Letters 461: 299-305.
Siu WY, Arooz T and Poon RYC (1999)
Differential responses of proliferating versus quiescent cells to adriamycin.
Experimental Cell Research 250: 131-41.
Yam CH, Siu WY, Arooz T, Chiu CHS, Lau A, Wang XQ and Poon RYC (1999)
MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins.
Cancer Research 59: 5075-8.
Yam CH, Ng RWM, Siu WY, Lau A and Poon RYC (1999)
Regulation of cyclin A-Cdk2 activity by SCF component Skp1 and F-box protein Skp2.
Molecular and Cellular Biology 19: 635-45.
Albrecht JH, Poon RYC, Ahonen CL, Rieland BM, Deng C, and Crary GS (1998)
Involvement of p21 and p27 in the regulation of CDK activity and cell cycle progression in the regenerating liver.
Oncogene 16: 2141-50.
Ng RWM, Arooz T, Yam CH, Chan IWY, Lau AWS and Poon RYC (1998)
Characterization of the cullin and F-box protein partner Skp1.
FEBS Letters 438: 183-9.
Pre-Poon Lab
Poon RYC and Hunter T (1998)
Expression of a novel form of p21Cip1/Waf1 in UV-irradiated and transformed cells.
Oncogene 16: 1333-43.
Hunter T and Poon RYC (1997)
Cdc37: a protein kinase chaperone?
Trends in Cell Biology 7: 157-61.
Poon RYC (1997)
Generation of phosphorylated cyclin-dependent kinase 2 and functional characterization of the Thr-160-specific phosphatase KAP.
Methods in Enzymology San Diego, Academic Press. 283: 283-92.
Poon RYC (1997)
Cell cycle control.
In Encyclopedia of Cancer. Ed. Bertino, J.R. Academic Press, San Diego 246-55.
Poon RYC, Chau MS, Yamashita K and Hunter T (1997)
The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells.
Cancer Research 57: 5168-78.
Poon RYC, Lew J and Hunter T (1997)
Identification of functional domains in the neuronal Cdk5 activator.
Journal of Biological Chemistry 272: 5703-8.
Mal A, Poon RYC, Howe PP, Toyoshima H, Hunter T, and Harter ML (1996)
Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFb-treated cells.
Nature 380: 262-5.
Poon RYC, Jiang W, Toyoshima H, and Hunter T (1996)
Cyclin-dependent kinases are inactivated by a combination of p21 and Thr14/Tyr15 phosphorylation after UV-induced DNA damage.
Journal of Biological Chemistry 271: 13283-91.
Poon RYC, Toyoshima H, and Hunter T (1996)
On the masking of signals on immunoblots by cellular proteins.
Journal of Immunological Methods 199: 155-8.
Poon RYC and Hunter T (1995)
Innocent bystanders or chosen collaborators?
Current Biology 5: 1243-7.
Poon RYC and Hunter T (1995)
Dephosphorylation of Cdk2 in the absence of cyclin by the CDK-interacting protein Cdi1/KAP.
Science 270: 90-3.
Poon RYC, Toyoshima H, and Hunter T (1995)
Redistribution of the CDK inhibitor p27 in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation.
Molecular Biology of the Cell 6: 1197-213.
Kobayashi H, Stewart E, Poon RYC and Hunt T (1994)
Cyclin A and cyclin B dissociate from p34cdc2 with half-times of 4 and 15 h, respectively, regardless of the phase of the cell cycle.
Journal of Biological Chemistry 269: 29153-60.
Poon RYC, Yamashita K, Howell M, Ershler MA, Belyavsky A and Hunt T (1994)
Cell cycle regulation of the p34cdc2/p33cdk2-activating kinase p40MO15.
Journal of Cell Science 107: 2789-99.
Poon RYC and Hunt T (1994)
Reversible immunoprecipitation using Histidine- or glutathione-S-transferase-tagged Staphylococcal protein A.
Analytical Biochemistry 218: 26-33.
Poon RYC, Yamashita K, Adamczewski JP, Hunt T and Shuttleworth J (1993)
The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2.
EMBO Journal 12: 3123-32.
Bandara LR, Adamczewski JP, Zamanian M, Poon RYC, Hunt T and La Thangue NB (1992)
Cyclin A recruits p33cdk2 to the cellular transcription factor DRTF1.
Journal of Cell Science Suppl. 16: 77-85.
Kobayashi H, Steward E, Poon R, Adamczewski JP, Gannon J and Hunt T (1992)
Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits.
Molecular Biology of the Cell 3: 1279-94.
Kobayashi H, Goldsteyn R, Poon R, Steward E, Gannon J, Minshull J, Smith R and Hunt T (1991)
Cyclins and their partners during Xenopusoocyte maturation.
Cold Spring Harbor Symposia on Quantitative Biology LVI: 437-47.
Kobayashi H, Minshull J, Ford C, Goldsteyn R, Poon R and Hunt T (1991)
On the synthesis and destruction of A- and B-type cyclins during oogenesis and meiotic maturation in Xenopus laevis.
Journal of Cell Biology 114: 755-65.